382 research outputs found
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A partial bibliography of the scientific publications of Dr. Jamie D. Villa
Integrative Biolog
SURFACE EXPRESSION OF TROUT CD4-1 AND CD4-2 DEFINES NOVEL POPULATIONS OF FUNCTIONALLY DISTINCT CD4+ T CELLS IN TELEOST FISH
International audienc
Socio-economic assessment of green infrastructure for climate change adaptation in the context of urban drainage planning
Green infrastructure (GI) contributes to improve urban drainage and also has other societal and environmental benefits that grey infrastructure usually does not have. Economic assessment for urban drainage planning and decision making often focuses on flood criteria. This study presents an economic assessment of GI based on a conventional cost-benefit analysis (CBA) that includes several benefits related to urban drainage (floods, combined sewer overflows and waste water treatment), environmental impacts (receiving water bodies) and additional societal and environmental benefits associated with GI (air quality improvements, aesthetic values, etc.). Benefits from flood damage reduction are monetized based on the widely used concept of Expected Annual Damage (EAD) that was calculated using a 1D/2D urban drainage model together with design storms and a damage model based on tailored flood depth–damage curves. Benefits from Combined Sewer Overflows (CSO) damage reduction were monetized using a 1D urban drainage model with continuous rainfall simulations and prices per cubic meter of spilled combined sewage water estimated from literature; other societal benefits were estimated using unit prices also estimated from literature. This economic assessment was applied to two different case studies: the Spanish cities of Barcelona and Badalona. The results are useful for decision making and also underline the relevancy of including not only flood damages in CBA of GI.This research was funded by the BINGO European H2020 project, Grant Agreement No.641739 and the RESCCUE European H2020 project, Grant Agreement No. 700174. The authors thank AMB, BCASA and the Municipalities of Badalona and Barcelona for their collaboration.Peer ReviewedPostprint (published version
Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods
Gas-exchange structures are critical for acquiring oxygen, but they also represent portals for pathogen entry. Local mucosal immunoglobulin responses against pathogens in specialized respiratory organs have only been described in tetrapods. Since fish gills are considered a mucosal surface, we hypothesized that a dedicated mucosal immunoglobulin response would be generated within its mucosa on microbial exposure. Supporting this hypothesis, here we demonstrate that following pathogen exposure, IgT(+) B cells proliferate and generate pathogen-specific IgT within the gills of fish, thus providing the first example of locally induced immunoglobulin in the mucosa of a cold-blooded species. Moreover, we demonstrate that gill microbiota is predominantly coated with IgT, thus providing previously unappreciated evidence that the microbiota present at a respiratory surface of a vertebrate is recognized by a mucosal immunoglobulin. Our findings indicate that respiratory surfaces and mucosal immunoglobulins are part of an ancient association that predates the emergence of tetrapods
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